How is a hba1c blood test done
Hemoglobin A1c (HbA1c) test for diabetes
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hemoglobin a1c test for diabetes hba1c
test improves the installation of two
parameters the first one is the
hemoglobin type II and second one is the
estimation of the glucose hemoglobin
type a is estimated as glycosylated
hemoglobin type a so this can be
estimated directly within the blood and
glucose can be estimated by whatever the
number of the glycosylated hemoglobin
type a present in the blood
so in this way the glucose levels can be
assessed based on the glycosylated HBA
levels in the plant
what is hemoglobin type real hemoglobin
present in the different types among
this type a having a subprocess like a
1a
a 1b and a1c among these a1c is used for
estimation of the glucose levels in the
plasma suppose hemoglobin is having a in
peptide structure like this now this n
terminal is the having the valine and
valine is an aliphatic amino acid with
alpha portion an amino group now this
amino group is responsive the attachment
of the glucose where the glucose is
going to be attached to form a
glycosylated hemoglobin and nowadays it
is called as glycated hemoglobin
reaction of the glucose with a minds how
this glucose is compliant with the
amides this is the section of the d
glucose now this DQ cause hang on of the
important facts row that is the aldehyde
function go now this audience group can
react with the a minds
a double bond is formed between the
carbon and nitrogen and this type of
compound is called as skips base in this
way glucose because of the aldehyde
function group can react with the
Alliance to form the skiffs base now let
us see the reaction of the glucose with
a hemoglobin so again the d glucose can
react with the hemoglobin and are we
have seen that hemoglobin type a1 C is
having n-terminal as the valine and vine
in his hand the nh-2 group at the Alpha
position now this aldehyde can react
with the amine group on the hemoglobin
and again it can form a a skiffs base
with the hemoglobin no because of this
condensation reaction it forms like ated
hemoglobin normally hemoglobin is have
the life span of 3 months there by the
glycated hemoglobin indicates that
glucose levels for the past 2 to 3
months in the plasma and one more
important thing is that the conversion
of the glucose to the glycated
hemoglobin is not an in geometric
process it is an ngon in genetic process
so suppose these are the erythrocytes
now these alito sizes are having average
lifespan of the 3 months and when the
glucose in the plasma reacts with these
edit row' sites it forms the
glycosylated hemoglobin or glycated
hemoglobin such that in fear of the
erythrocytes hemoglobin is going to be
attached with the glucose and few of the
hemoglobin SAR unreacted so whatever
that glucose attached to this
hemoglobin in the death row size is
called glycated hemoglobin and one more
important thing this glycated hemoglobin
cannot be detached very easily and the
process is somewhat reversible so they
can present for the three months the
entire lifespan of this arrow sites
that's why this glycated hemoglobin
indicates the
the average levels of the glucose for
the last three months how it is measured
the glycated hemoglobin levels can be
measured by immuno turn borough metric
SC suppose X is that glycated hemoglobin
levels and Y is the total hemoglobin
levels then we can estimate the
percentage of the hemoglobin a1c as X by
Y into 100 so hba1c is expressed in the
percent days where it is tomates the
number of the glycated hemoglobin levels
per the total number of high hemoglobin
levels in 200 what are the hba1c levels
so they can be classified as the normal
level 3 diabetic and diabetic levels so
among this the normal level is from 4.5
25.6% pre-diabetic levels include 5.7
26.4% days and the diabetic levels are
where the hba1c is greater than 6.5
percent so when the patient is hanging
hba1c levels within 5.7 26.4 they may
have a chance to be diabetic in future
and if any risk factors are associated
there is a risk for the generation of
the diabetes in the near future
and then the hba1c levels of grams and
6.5 it indicates the patient is and the
excess of glucose levels and patient is
in the diabetic states so what is a goal
of for controlling of the hba1c levels
the normal goal in the diabetic patients
is it is less than 7 percent so the
control of hba1c levels can be
identified based on which range they are
going to be present in the plasma for
example if they are from six point five
to seven percent the control is called
adequate control and 7 to 9 percent it
is inadequate as well as poor control
and when the HP ONC levels
that they're 9% it is called very poor
control
so the normal goal of treatment is to
reduce the hba1c levels less than 7%
limitations of the hba1c test so hba1c
tests mainly depends on the hemoglobin
levels in the plasma so any factors
which may either increase or decrease in
hemoglobin levels may affect the hba1c
measured values for example enemy
conditions like the aplastic anemia
megaloblastic anemia any of these
conditions can decrease the hemoglobin
levels within the plasma which may
decrease the hba1c
estimation in the patients similarly
liver failure can also decrease the
hemoglobin levels which will decrease
the the measured hba1c values similarly
in few of the conditions like the
jaundice where there is an increased by
lubing levels this behind rubin can
increase the hba1c levels because it can
also interact with the glucose they rate
the total estimated glycated hemoglobin
levels may be increase so any of these
factors may cause the alteration of the
HB unseeded levels so which should be
concerned before we are going for the
hba1c test in this way HB uncie test is
a very sensitive test for estimation of
this glucose levels and one of the
advantage of this test is that it can
estimate the average lucasz levels for
the past two to three months in the
patient which gives an indication since
that what is the levels of the glucose
live and how they are maintained for the
last two to three month and his VMC
level should be maintained less than 6.5
percent in the normal people and in the
diabetic people the goal is to achieve
the hba1c levels less than 7 percent
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