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Hemoglobin A1c (HbA1c) test for diabetes

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hemoglobin a1c test for diabetes hba1c

test improves the installation of two

parameters the first one is the

hemoglobin type II and second one is the

estimation of the glucose hemoglobin

type a is estimated as glycosylated

hemoglobin type a so this can be

estimated directly within the blood and

glucose can be estimated by whatever the

number of the glycosylated hemoglobin

type a present in the blood

so in this way the glucose levels can be

assessed based on the glycosylated HBA

levels in the plant

what is hemoglobin type real hemoglobin

present in the different types among

this type a having a subprocess like a

1a

a 1b and a1c among these a1c is used for

estimation of the glucose levels in the

plasma suppose hemoglobin is having a in

peptide structure like this now this n

terminal is the having the valine and

valine is an aliphatic amino acid with

alpha portion an amino group now this

amino group is responsive the attachment

of the glucose where the glucose is

going to be attached to form a

glycosylated hemoglobin and nowadays it

is called as glycated hemoglobin

reaction of the glucose with a minds how

this glucose is compliant with the

amides this is the section of the d

glucose now this DQ cause hang on of the

important facts row that is the aldehyde

function go now this audience group can

react with the a minds

a double bond is formed between the

carbon and nitrogen and this type of

compound is called as skips base in this

way glucose because of the aldehyde

function group can react with the

Alliance to form the skiffs base now let

us see the reaction of the glucose with

a hemoglobin so again the d glucose can

react with the hemoglobin and are we

have seen that hemoglobin type a1 C is

having n-terminal as the valine and vine

in his hand the nh-2 group at the Alpha

position now this aldehyde can react

with the amine group on the hemoglobin

and again it can form a a skiffs base

with the hemoglobin no because of this

condensation reaction it forms like ated

hemoglobin normally hemoglobin is have

the life span of 3 months there by the

glycated hemoglobin indicates that

glucose levels for the past 2 to 3

months in the plasma and one more

important thing is that the conversion

of the glucose to the glycated

hemoglobin is not an in geometric

process it is an ngon in genetic process

so suppose these are the erythrocytes

now these alito sizes are having average

lifespan of the 3 months and when the

glucose in the plasma reacts with these

edit row' sites it forms the

glycosylated hemoglobin or glycated

hemoglobin such that in fear of the

erythrocytes hemoglobin is going to be

attached with the glucose and few of the

hemoglobin SAR unreacted so whatever

that glucose attached to this

hemoglobin in the death row size is

called glycated hemoglobin and one more

important thing this glycated hemoglobin

cannot be detached very easily and the

process is somewhat reversible so they

can present for the three months the

entire lifespan of this arrow sites

that's why this glycated hemoglobin

indicates the

the average levels of the glucose for

the last three months how it is measured

the glycated hemoglobin levels can be

measured by immuno turn borough metric

SC suppose X is that glycated hemoglobin

levels and Y is the total hemoglobin

levels then we can estimate the

percentage of the hemoglobin a1c as X by

Y into 100 so hba1c is expressed in the

percent days where it is tomates the

number of the glycated hemoglobin levels

per the total number of high hemoglobin

levels in 200 what are the hba1c levels

so they can be classified as the normal

level 3 diabetic and diabetic levels so

among this the normal level is from 4.5

25.6% pre-diabetic levels include 5.7

26.4% days and the diabetic levels are

where the hba1c is greater than 6.5

percent so when the patient is hanging

hba1c levels within 5.7 26.4 they may

have a chance to be diabetic in future

and if any risk factors are associated

there is a risk for the generation of

the diabetes in the near future

and then the hba1c levels of grams and

6.5 it indicates the patient is and the

excess of glucose levels and patient is

in the diabetic states so what is a goal

of for controlling of the hba1c levels

the normal goal in the diabetic patients

is it is less than 7 percent so the

control of hba1c levels can be

identified based on which range they are

going to be present in the plasma for

example if they are from six point five

to seven percent the control is called

adequate control and 7 to 9 percent it

is inadequate as well as poor control

and when the HP ONC levels

that they're 9% it is called very poor

control

so the normal goal of treatment is to

reduce the hba1c levels less than 7%

limitations of the hba1c test so hba1c

tests mainly depends on the hemoglobin

levels in the plasma so any factors

which may either increase or decrease in

hemoglobin levels may affect the hba1c

measured values for example enemy

conditions like the aplastic anemia

megaloblastic anemia any of these

conditions can decrease the hemoglobin

levels within the plasma which may

decrease the hba1c

estimation in the patients similarly

liver failure can also decrease the

hemoglobin levels which will decrease

the the measured hba1c values similarly

in few of the conditions like the

jaundice where there is an increased by

lubing levels this behind rubin can

increase the hba1c levels because it can

also interact with the glucose they rate

the total estimated glycated hemoglobin

levels may be increase so any of these

factors may cause the alteration of the

HB unseeded levels so which should be

concerned before we are going for the

hba1c test in this way HB uncie test is

a very sensitive test for estimation of

this glucose levels and one of the

advantage of this test is that it can

estimate the average lucasz levels for

the past two to three months in the

patient which gives an indication since

that what is the levels of the glucose

live and how they are maintained for the

last two to three month and his VMC

level should be maintained less than 6.5

percent in the normal people and in the

diabetic people the goal is to achieve

the hba1c levels less than 7 percent

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